The Reaction Biology HMT Activity Mapper is a dedicated data-visualization and software module within Reaction Biology’s software suite. It allows drug-discovery researchers to visually map, track, and cross-reference compound inhibition data against a broad profile of Histone Methyltransferases (HMTs). HMTs are critical epigenetic enzymes that add methyl groups to histones to regulate gene expression. When mutated or dysregulated, they frequently drive oncology, immunological, and neurodegenerative diseases.
Rather than relying on flat data spreadsheets, researchers use the mapper tool to color-code compound activities directly onto a unified biological landscape. This helps them quickly pinpoint selectivity, target engagement, and off-target profiles across the entire enzyme family. Core Features of the HMT Activity Mapper
Interactive Activity Profiling: Users manually enter or auto-import raw compound data (such as IC50IC sub 50
or percentage inhibition values) into the software interface.
Dynamic Color-Coding: The tool applies a visual gradient over a structural or relational enzyme map. Highly potent inhibition highlights target enzymes in one color (e.g., deep red), while inactive off-targets remain cold or uncolored.
Scalable Map Customization: Researchers can zoom, reposition, and export high-resolution, publication-ready vector graphics or PDF files to showcase an inhibitor’s selectivity fingerprint.
Flexible Enzyme Insertion: The interface allows custom addition or spatial editing of target enzymes by tracking precise X/Y grid coordinates. The Underlying Assay Engine: HotSpot™ Technology
The data driving the HMT Activity Mapper primarily originates from Reaction Biology’s Methyltransferase Assay Services. These services use the HotSpot™ platform, widely recognized as an industry standard for profiling epigenetic targets: Mapper-Instructions.pdf – Reaction Biology
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